学位:千大院医薬博甲第薬177号

This thesis concerns the synthesis and biological evaluation of microtubules (MT) inhibitors of the type 2-aryl-1,4-naphthoquinone-1-oxime methyl ether.Following a comprehensive review on MT and MT targeting drugs, the first part of the Results and Discussion section (Chapter 2) of the thesis, a library of derivatives of 2-aryl-subtituted (Chapter 3) are described and evaluated for their inhibitory activity against tubulin in Hela cell culture.