Foxp3 and autoimmunity : transcription regulation and partner proteins

[SUMMARY] Regulatory T（T reg）cells play critical roles in maintaining immune homeostasis, and the development of this unique T cell subset is dependent on the master transcription factor, Foxp3. The transcription of Foxp3 is tightly regulated by several regulatory elements. While there is accumulating evidence that multiple transcription factors promote Foxp3 expression at steady-state conditions, little is known about how Foxp3 expression is controlled under inflammatory conditions. Although the expression of Foxp3 is sufficient to induce the suppressor function in murine CD4＋ T cells, Foxp3-binding proteins are required for the appropriate T reg suppressor function. Thus, the precise understanding of Foxp3-containing transcription complex is important for optimizing T reg cell-based therapy for autoimmune diseases. In this review, the molecular mechanisms underlying the regulation of Foxp3 expression, especially under inflammatory conditions, are summarized. Further, Foxp3 partner proteins and T reg cell function are also discussed.

https://opac.ll.chiba-u.jp/da/curator/107790/

https://opac.ll.chiba-u.jp/da/curator/107790/S03035476-96E-1-P1.pdf

The Chiba Medical Society

千葉医学会

学術雑誌論文

AN00142148

Chiba medical journal

96E

1

1

4

2019-02-10

10.20776/S03035476-96E-1-P1

publisher

Chiba Medical Journal (ONLINE ISSN 2433-4235)