[SUMMARY] This study verified the Effectiveness of “Support Behavior Indicators”（Nohmi et al, 2018） for nurse managers toprovide support to mid-career nurses with 5 to 10 years of clinical experience, who do not have a professional title, insetting goals as professional employees in acute-care hospitals. A trial was conducted in which a nurse manager used the indicators through a goal setting interview with amid-career nurse and assisted the nurse in setting goals. This study conducted semi-structured interviews with bothnurse managers and mid-career nurses individually and asked them about the process of goal setting as well as worktoward achieving the three-months goals. Through interviews, questions related to effectiveness were asked to headnurses for obtaining clues to support the setting of goals as well as improve the support. Those asked to mid-careernurses were related to goal setting and the situation of work toward achieving goals as professional employees. Thecollected interview data were qualitatively analyzed.Ten managers in three facilities used the indicators in a trial, in which they provided support to 13 mid-careernurses in setting goals. It was found that managers understand the situation in which mid-career nurses are havingdifficulties in setting goals as professional employees as well as the background there to, based on the indicator “the situation in which mid-career nurses have difficulty in setting goals.”. The managers increased their awareness of theirroles in providing support for setting goals. Furthermore, the support that they provided （e.g., asking the subjects about their image of the future and conveying role expectations to them） improved from a deepening of theirunderstanding of the subjects （mid-career nurses）, which was attained through observation and inquiry and based on〈support behavior examples〉. Mid-career nurses acknowledged support from nurse managers and started building theircareer vision. This helped them increase their awareness of the importance of contributing to the organization and acquire the necessary knowledge. All such nurses set goals as professional employees and worked toward achieving them. The managers were able to provide support for goal setting that addresses the characteristics of each mid-careernurse, nurses who are professional employees with role expectations, by adopting different means. These meansincluded perceiving the support needs of the mid-career nurses multi-laterally and overall based on the［the situation］and （sub-category items of the situation） of indicators and by conversing with the mid-career nurses themselves. The indicators are believed to be effective in improving “goal setting interviews,” which are for providing support for goal setting.