甲斐, 啓嗣

綾野, 雄幸

HIRAYAMA (KATAYAMA), Keiko

KAI, Keishi

WATANABE, Yukio

AYANO, Yuko

[Abstract] In order to find out the mechanisms by which poorly digestible raw amylomaize starch lowers the serum cholesterol level in rats, both two feeding experiments and in vitro measurements for the interaction of the starch with bile salts were carried out. Each carbohydrate source was included at 78-1.977463e+00vel in a cholesterol free diet with or without antimicrobial drugs and fed weaning male Wistar rats for 22 days. The animals fed amylomaize starch showed significantly lower serum cholosterol level than those on sucrose or normal corn starch. The rats given normal corn starch in a restricted amount as with identical energy consumed by their counterparts on amylomaize starch maintained serum cholesterol unaltered. Furthermore, antimicrobial drugs supplemented to normal corn and amylomaize starch diets failed to modify serum cholesterol. Raw potato starch, another poorly digestible starch, was also found to exhibit remarkable hypocholesterolemic effect compared to sucrose. In in vitro study, amylomaize starch was proved to adsorb more taurocholate and to inhibit more efficiently the absorption of ^<14>C-cholate by everted ileum sacs than normal corn starch. These findings indicate that amylomaize starch presumably exerts the hypocholesterolemic action by depressing the intestinal reabsorption of bile salts through adsorbing them on undigested starch granules staying in the lower bowel.