Recent worldwide globalization in economics, politics, religions, cultures, life styles, transportation, is causing emerging and re-emerging parasitic diseases. Parasites and parasitic diseases once were seemed to be eradicated form Japan and economically established countries, but parasites and parasitic diseases have been evolving along with establishing of recent high technology medicine. Many opportunistic parasites such as Toxoplasma, Blastocystis, Neospora, Cyclospora, Cryptosporidium, Microspora, etc. are watching for a chance to infect high leveled immunocompromised patients whose lives are supported by the modern high technology medicine. Classical parasites are also fighting against advancing medicine by acquiring drug resistance. Toxoplasma induces autoimmunity in the patients and has been revealed to cause autoimmunity and also new types of infectious diseases such as non-infected congenital toxoplasmosis. We have to reexamine and reconciling modern advancing high technology medicine based on comprehensive policies by learning from the evolving parasites and parasitic diseases.