原著

長尾,孝一

桑原,竹一郎

上野,哲夫

丸山,孝士

鈴木,通也

将基面,誠

吉原,暉文

NAGAO,KOICHI

KUWAHARA,TAKEICHIRO

UENO,TETUO

MARUYAMA,KOSHI

SUZUKI,MICHIYA

SYOOGIMEN,MAKOTO

YOSHIWARA,TERUBUMI

During a period from 1973 to 1979, 8 patients (including 4 unmarried women) with malignant germ cell tumor of the ovary were treated at our clinic. By the W. H. O. classification, these cases included 1 case of embryonal carcinoma, 1 case of dysgerminoma, 2 cases of endodermal sinus tumor, 1 case of teratoma mixed wtih choriocarcinoma, 1 case of teratoma mixed with endodermal sinus tumor and 2 cases of dysgerminoma mixed with endodermal sinus tumor. Clinicopathological findings of these patients were reviewed in association with the serum level of "tumor products" including AFP, HCG, CEA and LDH. The age ranged from 15 to 43 years (average 28 years). The serum level of AFP was elevated in all patients with endodermal sinus tumor. The serum level of HCG was elevated in only 1 case of choriocarcinoma mixed with teratoma in which HCG was identified by the immunoperoxidase technique in choriocarcinoma cells. The serum level of LDH was elevated in all patients with lethal tumors. The measurement of the serum level of specific tumor products were helpful in determining the extention and recurrence of the tumors and prognosis of patients. While lymph node metastasis was seen in 1 case of embryonal carcinoma and visceral organ metastasis was seen in 2 cases of teratoma mixed with choriocarcinoma, and embryonal carcinoma, peritoneal carcinomatosis was seen in all patients, indicating the rapid growth rate of these tumors.