[SUMMARY] This study aims to understand the parenting behavior, emotions toward parenting, and the perceptions about their infants’ medical condition that are held by mothers who raise infants with single ventricle heart defects (SVCHD) at home, and to ascertain aspects of childcare based on these three parameters. Semi-structured interviews were conducted with nine mothers of infants with SVCHD, and the data was qualitatively analyzed.The results were as follows. First, mothers got anxious when their infants cried, regardless of the presence of cyanotic symptoms. Mothers were able to recognize the heart-failure symptoms, which is said to be difficult to identify, from experience during infants’ hospitalization and the state of feeding. While they understood the complexities of the heart disease, however, they often regarded the infant’s weight as a sign of good growth. Second, it was difficult for the mothers to learn parenting through trial and error, since special measures were warranted to manage the heart disease. Finally, three aspects of parenting for infants with SVCHD were identified: manifesting positive emotions about their parenting style through trial-and-error parenting and mother–infant interactions, while maintaining strict fluid intake restriction; feeling uncertain and helpless in caring for infants with obvious symptoms, even after exercising caution; and realizing normal parenting styles for infants with the heart disease but no severe symptoms or special-restrictions needs. These findings suggest that it is important to support for mothers to instill positive emotions, which can be achieved by promoting mother-child interaction from both aspects of childcare that responds to infants’ needs, including disease management, and emotional aspects of joy for the child's growth and confidence in their parenting.