[SUMMARY] In order for cancer patients to better spend the end of their lives, it is important for patients to thoroughly discuss their wishes with their healthcare providers and their families, and to promote end-of-life care based on the patient’s will. However, in Japan, the discussion is not done often enough. The purpose of this study is to develop a nursing program for family members of patients with advanced cancer to promote end-of-life discussions between the patients and the family members. 【Phase Ⅰ】 I reviewed domestic and international literature for the purpose of clarifying problems concerning end-of-life discussions between cancer patients and their families. I analyzed six Japanese and six English research articles, and four categories were derived as “Manifestations” of the problem, ten categories were derived as “Determinants” and four categories were derived as “Consequences.” 【Phase Ⅱ】 Based on the results of Phase I and social cognitive theory, I constructed the framework of the nursing program, and as an educational tool used in the program, “A guidebook for family members of patients with advanced cancer to promote end-of-life discussions.” In order to clarify the problems of the “guidebook,” an interview survey was conducted for expert end-of-life cancer nurses. The twelve categories were extracted regarding problems in the guide book, then the guidebooks were modified based on the results. The framework of the nursing program and the guidebook were constructed based on the problems about end-of-life discussions of cancer patients identified by literature reviews and social cognitive theory. I also modified the guidebook based on the opinions of expert nurses. In the future, it is necessary to try the program and clarify the effect of the program.