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S03035476-98E-1-P1 pdf 1.65 MB 243

基本情報

データ種別：学術成果リポジトリ

タイトル
[Chiba Medical Society Young Investigator Award Minireview] Epigenetic contribution to tumorigenesis of host cells by Epstein-Barr virus infection
作成者
FUJII, Takahiro
OKABE, Atsushi
作成者ID
1000080778118
研究者リゾルバ
KANEDA, Atsushi
作成者ID
1000010313024
研究者リゾルバ
作成者の別表記
藤井, 貴大
岡部, 篤史
1000080778118
研究者リゾルバ
金田, 篤志
1000010313024
研究者リゾルバ
内容
[ABSTRACT] Epstein-Barr virus (EBV) is known as an oncogenic virus and causes tumors in a variety of tissues, including lymphocytes and epithelial cells. EBV infects host cells latently as an episome and affects the host genome and epigenome while switching between three types of latent stages and a lytic stage. In recent years, the development of analytic methods using next generation sequencing and chromosome conformation capture technologies has enabled us to identify abnormalities at the molecular level in cancer cells. In EBV-positive tumors, pigenetic alterations such as DNA methylation, viral miRNA-mediated expression changes, and aberrations in histone modification and 3D chromatin structure, together with the involvement of EBV, have been revealed by analysis of tumor cells and in vitro EBV infection experiments. Further understanding of host-EBV interactions and their roles in the cancer pathogenesis is expected to lead to the development of revolutionary therapies targeting the epigenome. Here we review epigenetic contribution to tumorigenesis by EBV infection in host cells.
ハンドルURL
https://opac.ll.chiba-u.jp/da/curator/900120227/
フルテキストへのリンク
https://opac.ll.chiba-u.jp/da/curator/900120227/S03035476-98E-1-P1.pdf
公開者
The Chiba Medical Society
公開者の別表記
千葉医学会
NII資源タイプ
学術雑誌論文
ISSN
03035476
24334235
NCID
AN00142148
掲載誌名
Chiba medical journal
巻
98E
号
1
開始ページ
1
終了ページ
7
刊行年月
2022-02-10
selfDOI
10.20776/S03035476-98E-1-P1
著者版フラグ
publisher
カテゴリ
Chiba Medical Journal (ONLINE ISSN 2433-4235)